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Nutrigenomic Disease

Food delivers not just calories, macronutrients, micronutrients or antioxidant phytonutrients, but information. Food "speaks" to our genes, providing a snapshot of the state of affairs of the world in which we live. At the genetic level, the newscast provided by the foods pets eat has a significant epigenetic impact on what portions of their genome will be expressed, the phenotype they will display, how they age, and what diseases they develop. Food that is not genetically appropriate and starved of nutrients, signals genetic expression that can increase susceptibility to a host of diseases. (Integrative Medicine, Vol 8, No. 5, 2009, page 49).

• “…the possibility, even the likelihood, that grandmaternal diets contributed to the incidence of obesity and diabetes…” Cooney, C. Germ cells carry the epigenetic benefits of grandmother’s diet. Proceedings of the National Academy of Sciences, 2006.
• “…Nutritional restriction during gestation could affect epigenetic programming in the brain…evidence for a stable yet dynamic epigenome capable of regulating phenotypic plasticity through epigenetic programming.” McGowan, P., et al. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Research, 1237, 12-24, 2008.
• “…strong pointers to the importance of fetal adaptations invoked when the maternoplacental nutrient supply fails to match the fetal nutrient demand.” Godfrey, K. and D. Barker. Fetal nutrition and adult disease. American Journal of Clinical Nutrition, 71 (5), 1344S-1352S, 2000.
• “…most monozygotic twins are not identical…existence of epigenetic differences…” Fraga, M. R., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences, 2005.
• “…nutritional environment encountered during fetal life is strongly implicated as a determinant of lifelong metabolic capacity and risk of disease…prenatal protein restriction programs development of a metabolic syndrome-like phenotype that develops only with senescence…” Erhuma, A., et al. Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism... American Journal of Physiology – Endocrinology and Metabolism, 292, E1702-E1714, 2007.

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